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Leica DM4 B & DM6 B Upright Microscopes

ncrease your work efficiency with the Leica DM4 B or Leica DM6 B upright digital research microscopes! Both are ideally suited to making your work life easier in biomedical research and clinical labs alike.



DM4 B & DM6 B_Brochure_EN

Leica DM4 B & DM6 B Upright Microscopes

Intelligent Automation for Life Science and Clinical Applications

Increase your work efficiency with the Leica DM4 B or Leica DM6 B upright digital research microscopes! Both are ideally suited to making your work life easier in biomedical research and clinical labs alike.

  • Simplify your workflow with automated functions and easy-to-use software
  • Easily capture publication-quality images by utilizing the 19-mm sCMOS camera imaging port
  • Create fast overviews of your samples and identify the important details instantly with the LAS X Navigator Software
  • Have great flexibility through the choice of accessories

DM4 B & DM6 B


See More in Less Time

Saving time in image acquisition means you have more time for what is really at the heart of your science. Here are just a few ways to speed up your workflow.

  • See up to 10.000x more of your sample with the LAS X Navigator. Set up high resolution image acquisition for slides, dishes and multiwell plates
  • Take full advantage of your sCMOS camera, for example the Leica DFC9000! The 19-mm field of view camera port perfectly fits the dimensions of common sCMOS sensors.
  • Make your slide examination faster at the highest resolution.
  • Choose the objective that best fits your application – from a range of more than 300 outstanding optics. Just one example: the unique 1.25x overview objective for a perfect wideview.

19-mm field of view


Free Your Mind!

Focus on the result you would like to achieve rather than the process of getting to it. Intelligent Automation does the work for you: It solves multi-step routines with the press of a button, makes your work life easier, saves time, and allows you to focus on your experiment, not on complex microscope settings.  

  • Change contrast with the push of a button – everything you need automatically slides into place.
  • Acquire publication-ready images.
  • Use Light and Contrast Management to simplify your work – for example the Fluorescence Intensity Manager (FIM), fast Internal Filter wheel (IFW) and Excitation Manager (ExMan) for fluorescence images, or Koehler light management for perfect Koehler images.

Free Your Mind


Exactly What You Need

You can configure the microscope that fits your need and budget with the Leica DM4 B and Leica DM6 B. Optimize your system to your application with different contrast methods and automated functions.

LED illumination lights your sample homogenously and with a constant color temperature, while also saving energy and avoiding bulb changes due to the LED’s lifetime of up to 25,000 hours

Exactly What You Need


Make Your Microscope an Imaging System

Leica Microsystems provides powerful cameras and workflow-based software to complete your integrated imaging system.  

  • Leica Application Suite X (LAS X) is our easy-to-use workflow-based software which guides you step by step to acquire the images you need.
  • Leica microscope cameras cover a broad range of applications from brightfield to fluorescence applications – or even one camera for multi-purposes both such as our Leica DFC7000 T camera

The Leica DM6 B Upright Microscope includes the Leica DFC7000 T Camera and LAS X Software.

The Leica DM6 B Upright Microscope includes the Leica DFC7000 T Camera and LAS X Software.


Electrophysiology and Neurobiology with the Leica DM6 FS

If you need a microscope system to support you in neuroscience, evolutionary biology, or in vivo imaging, the Leica DM6 FS fixed stage widefield microscope should be your first choice. It is ideal for applications where you need to stimulate specimens from the outside like in optogenetics, or measure them in electrophysiological experiments such as patch clamp.

Your advantages in a nutshell

  • Vibration-free control ensures your sample is not disturbed.
  • All current-carrying elements are switched off if not in use, preventing sample disruption.
  • More clearance gives you easy access to samples.

Configured from the same stand as the Leica DM6 B, it is an outstanding tool for sophisticated experiments and also forms part of the Leica EM Cryo CLEM system.

Leica DM6 FS


Sample Preparation with Laser Microdissection

Facilitate sample preparation and achieve pure, contamination-free starting material for molecular biology analysis directly from a tissue section! Laser microdissection (LMD) helps you to isolate a precise region of interest, retaining cell morphology by separating your target cells from the rest of the sample. 

How do the Leica LMD systems work? 

  • The laser moves, not the sample. This is why the cuts are fast and clean.
  • Dissectates are collected via gravity directly into standard consumables, saving time and money.
  • Cut various preparations: fresh, frozen, fixed, or immuno-labeled samples, live cells, smear preparations, bone, plant, wood, dentin, and many more.

Leica LMD systems

System Overview

Leica DM4 B

Leica DM6 B

Stand Power supply integrated within stand within electronics box CTR6 or CTR6 LED
Display information display Leica SmartTouch with information and controls
Interfaces 1 x USB 2.0, 1 x I2C

2 x ;USB 2.0,;2 x I2C

Operation Focus mechanical motorized or mechanical
2-ratio gearbox (coarse/fine) 5 electronic ratios
  includes parfocal function
  switch between coarse and fine mode
  memory locations for two z-positions
Objective turret absolute coded motorized or coded
– 6x M25 thread includes dry and immersion mode

– 7x M25 thread (optional))

7x M25 thread
Stage mechanical motorized (optional)
ceramic-coated with stepper motor
y-drive with belt switch between fast and precision mode
removable stage drive with adjustable torque includes memory location for up to
110° swivel 5 stage positions
left-handed version optionally available mechanical
  y-drive with belt
  removable stage drive with adjustable torque
  110° swivel
  left-handed version optionally available
Controls 6 programmable function buttons 6 programmable function buttons
controls for z (focus) movement and x,y (stage)
4 programmable function buttons
Leica STP8000
controls for z (coarse and fine focus)
and x,y (stage) movement
11 programmable function buttons
touchpanel with information and control panels
Specimen overview tool



light axis


either 12 V 100 W halogen lamp or LED
Light manager: automatic Köhler light management
sets the best values for aperture, field
diaphragm, and light intensity



Contrast manager: switch from one contrast

method to another with one push of a button



Constant Color Intensity Control: maintains a
constant color temperature (3200 K)
Not necessary for LED Yes for Halogen versions
Not necessary for LED
Contrast method



DIC (fully automatic)

Motorized filter cube turret 5x 5x

Leica EL6000

Leica EL6000

Leica SFL100/4000

Leica SFL4000/7000

3rd Party 3rd Party
Fluorescence Intensity Manager (FIM): regulation
of the excitation light to effectively protect
the specimen from photo bleaching



Contrast manager: switch from one contrast
method to another with one push of a button



Round and square illuminated field diaphragms
for ocular and camera observation (motorized)



Excitation Manager: balances fluorescence
when viewing multiple probes simultaneously
Condensers Automation condenser head, motorized condenser head, motorized
7x condenser disk, motorized (optional) 7x condenser disk, motorized (optional)
polarizer, motorized (optional) polarizer, motorized (optional)