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Leica Fluorescence Microscope DM2500

Leica DM2500 & DM2500 LED optical microscopes are tools for demanding tasks in life science routine and research applications. With their transmitted light illumination, optical performance, and state-of-the-art accessories, they are especially well-suited for challenging life science research tasks that require differential interference contrast or high-performance fluorescence.



Leica DM2500 & DM2500 LED Optical microscopes

Leica DM2500 & DM2500 LED optical microscopes are tools for demanding tasks in life science routine and research applications. With their transmitted light illumination, optical performance, and state-of-the-art accessories, they are especially well-suited for challenging life science research tasks that require differential interference contrast or high-performance fluorescence.

The difference between the two optical microscopes is their illumination: DM2500 LED is equipped with LED illumination for transmitted light, DM2500 works with halogen. Both types of illumination render a realistic impression of the colors of the sample, so that users in clinical applications, such as the frequently used HE specimen staining, are able to assess the colors of their samples accurately.

Designed with application-oriented modularity, the DM2500 & DM2500 LED can be configured to fit a wide variety of applications and accommodate the diverse physical requirements of individual users.

The microscopes are certified for in-vitro-diagnostics (IVD).



Constant color temperature with LED illumination

High-performance LED illumination for analyzing in brightfield, DIC, and phase contrast. An added benefit when using LED transmitted light illumination is the constant color temperature at all light intensity levels. The ultra-bright LED illumination is suitable for all transmitted light contrasting methods. Due to the long life of an LED, Leica DM2500 LED also save the time and money spent on changing halogen lamps.

Constant color temperature with LED illumination


Perfect fit

Use the unique, height-adjustable focus knobs and easy-to-change stage controls to customize the Leica DM2500 & DM2500 LED for individual users. Along with the other ergonomic equipment available, such as tilting tubes, intermediate modules, and a series of brightness-synchronized objectives, users will feel better after a long day of microscopy work.

Perfect fit


Clear and bright illumination

The high-performance illumination with the DM2500 and DM2500 LED provide an even field of view and is ideal not only for analyzing stained specimens in brightfield, but also for viewing unstained objects in DIC and phase contrast.

Clear and bright illumination


High-performance fluorescence

High-performance fluorescence with Zero Pixel Shift Technology, differential interference contrast, phase, and polarization contrast – Leica DM2500 & DM2500 LED offer a variety of application options to meet the challenging demands of biomedical research.

High-performance fluorescence


Large selection of high class objectives

When the microscope is used for a wide range of applications, a larger selection of high class objectives is often required. To accommodate all necessary objectives at the same time, the innovative Leica DM2500 & DM2500 LED feature an optional 7-fold objective nosepiece.

Large selection of high class objectives


Stay in control

Stay in control


Share and compare

Make sharing images easy with Leica DMShare. Wirelessly view a live image from the microscope camera on one or multiple tablets with this app-based solution. Available for both iPad and Android tablets.




Multiview microscopes Leica Multiviews
Leica Microsystems produces multiview systems with precision-coated glass optics that provide excellent image quality for each observer.

Accessories are attached to the microscope, allowing multiple users to observe the same specimen at the same time, thus achieving the realism of working together using a microscope.

Standard system configurations are available for 2, 3, 4, 5, 10 users simultaneously, and up to 20 users depending on customer needs

Multiview for 2 Multiview for 10




HCS(Harmonic Contrast System) Infinity Optical System
Stand Power supply External 4 W/90–250 V
Koehler Variable Koehler illumination
Prefixed Koehler (option)
Eyetubes Ergotube 15° viewing angle FOV 22*
Standard tube 30° viewing angle FOV 22
Ergo tilting eyetube FOV 25 (long)
Ergo tilting eyetube FOV 22 (short)
Advanced ergo tilting eyetube FOV 22
Phototubes Trinocular ergo tilting phototube 50/50 FOV 22
Trinocular ergo tilting phototube 100/100 FOV 25
Trinocular ergo tilting phototube 50/50 FOV 25
BDT25 0/50/100 dual port option FOV 25
EDT22 50/50 FOV 22



Operation Focus Height adjustable focus knobs*
5 focus functions: 2- or 3-gear focusing, focus-stop,
adjustable torque*
Objective Brightness synchronized objective series 4x, 10x, 40x*
Objective turret 6-fold
Stage Ceramic-coated (ultra hard ceramic)*
Left/right (exchangeable by user)*
Telescopic drive
Adjustable torque
Rotatable / stage for two slides (option)
TL axis illumination TL illumination: LED
Filtering Flip-out blue filter
Filter holder for 2 filters
Filter magazine for 3 filters
Condenser – Standard condenser CL/PH color coding* (2.5x–100x)
– Achr. Apl. Flip top condenser color coding* (1.25x–100x)
– Universal condenser UCL BF/Phase/DF
– Universal condenser UCA BF/Phase/DF/DIC
Contrast methods


Fluo-axis Illumination 50 W Hg
75 W Xe
100 W Hg
LED lamp
Filter cube
5-position filter cube turret

* New unique features